CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE
Document Type : Original Research Articles
Abstract
The current study was conducted to investigate the effect of unpredictable chronic mild stress as a model of depression on the physiological and neurochemical parameters of male swiss mice. Twenty- Five adult male Swiss albino mice were housed in either control group or unpredictable chronic mild stress (UCMS) group that was exposed to different physical stressors for 8 weeks. Plasma corticosterone and brain stem levels of dopamine and serotonin (5-OH) were measured. UCMS mice displayed an increase in the plasma corticosterone concentration and lower levels of both brain stem dopamine and 5- OHT compared to controls. In conclusion, the presence of physiological changes along with the significant neurobiological changes in the brain strongly support the efficacy of UCMS as a model of depression in the human being.
(2018). CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE. Journal of the Egyptian Veterinary Medical Association, 78(2), 301-308.
MLA
. "CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE", Journal of the Egyptian Veterinary Medical Association, 78, 2, 2018, 301-308.
HARVARD
(2018). 'CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE', Journal of the Egyptian Veterinary Medical Association, 78(2), pp. 301-308.
VANCOUVER
CONSEQUENCES OF UNPREDICTABLE CHRONIC MILD STRESS (UCMS) AS A MODEL OF DEPRESSION ON THE PHYSIOLOGICAL AND NEURO CHEMICAL PARAMETERS OF MALE SWISS MOUSE. Journal of the Egyptian Veterinary Medical Association, 2018; 78(2): 301-308.
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